Last update :
18/07/2024
References   References 2286  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=1576

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Ben M, Trusley C, Kupiec TC, Trissel LA.
Title : Physical and chemical stability of palonosetron hydrochloride with glycopyrrolate and neostigmine during simulated Y-site administration.
Reference : Int J Pharm Compound ; 12, 4: 368-371. 2008

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionGlycopyrronium bromide Antimuscarinic
Compatible 0,2 mg/ml + injectionNeostigmine methylsulfate 0,5 mg/ml + None
Compatible 0,2 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + None
injectionNeostigmine methylsulfate Various
Compatible 0,5 mg/ml + injectionGlycopyrronium bromide 0,2 mg/ml + None
Compatible 0,5 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + None
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionGlycopyrronium bromide 0,2 mg/ml + None
Compatible 50 µg/ml + injectionNeostigmine methylsulfate 0,5 mg/ml + None
Stability of mixtures
Glass None 25°C Not specified
injection Palonosetron hydrochloride 25 µg/ml
injection Neostigmine methylsulfate 0,25 mg/ml
4 Hour
Glass None 25°C Not specified
injection Palonosetron hydrochloride 25 µg/ml
injection Glycopyrronium bromide 0,1 mg/ml
4 Hour

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