Last update :
14/12/2024
References   References 2248  
Type : Journal

Research teams : San Francisco - Elan Pharmaceuticals Inc
Authors : Shields D, Montenegro R.
Title : Chemical stability of ziconotide-clonidine hydrochloride admixtures with and without morphine sulfate during simulated intrathecal administration.
Reference : Neuromodulation ; 10, 1: 6-11. 2007

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Stability indicating capability inadequately assessed

List of drugs
injectionClonidine hydrochloride Antihypertensive
injectionZiconotide acetate Analgesic
Stability of mixtures
Not specified Sodium chloride 0,9% 37°C Protect from light
injection Clonidine hydrochloride 2 mg/ml
injection Ziconotide acetate 25 µg/ml
60 Day

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