Last update :
19/11/2024
References   References 2188  
Type : Journal
Web link : http://archive.eahp.eu/EJHP-Science-archive/Issue-2-2007

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Karstens A, Krämer I.
Title : Chemical and physical stability of diluted busulfan infusion solutions.
Reference : EJHP Science ; 13, 2: 40-47 2007

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionBusulfan Anticancer drug
Factors which affect stability Temperature 4°C Induces Precipitation
Factors which affect stability Temperature -20°C Induces Precipitation
Stability in solutions Glass Sodium chloride 0,9% 0.5 mg/ml 13-15°C Protect from light
36 Hour
Stability in solutions Glass Sodium chloride 0,9% 0.5 mg/ml 2-8°C Protect from light
48 Hour
Stability in solutions Polypropylene Sodium chloride 0,9% 0.5 mg/ml 13-15°C Protect from light
36 Hour
Stability in solutions Polypropylene Sodium chloride 0,9% 0.5 mg/ml 2-8°C Protect from light
19 Hour

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