Last update :
29/10/2024
References   References 2022  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S0885392405002460

Research teams : Glasgow - University of Strathclyde, Department of Pharmaceutical Sciences
Authors : Watson DG, Lin M, Morton A, Cable CG, McArthur DA.
Title : Compatibility and stability of dexamethasone sodium phosphate and ketamine hydrochloride subcutaneous infusions in polypropylene syringes.
Reference : J Pain Symptom Manage ; 30: 80-86. 2005

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.07 mg/ml + injectionKetamine hydrochloride 3.57 & 42.85 mg/ml + Sodium chloride 0,9%
injectionKetamine hydrochloride General anesthetic
Compatible 3.57 & 42.85 mg/ml + injectionDexamethasone sodium phosphate 0.07 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 23°C Light
injection Ketamine hydrochloride 3,6 & 42,8 mg/ml
injection Dexamethasone sodium phosphate 0,07 mg/ml
8 Day
Polypropylene Sodium chloride 0,9% 37°C Light
injection Ketamine hydrochloride 3,6 & 42,8 mg/ml
injection Dexamethasone sodium phosphate 0,07 mg/ml
8 Day
Polypropylene Sodium chloride 0,9% 4°C Light
injection Ketamine hydrochloride 3,6 & 42,8 mg/ml
injection Dexamethasone sodium phosphate 0,07 mg/ml
8 Day

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