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References   References 1938  
Type : Journal
Web link : https://doi.org/10.1345/aph.1D564
Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Boitquin LP, Hecq JD, Vanbeckbergen DF, Jamart J, Galanti LM.
Title : Stability of sufentanil citrate with levobupivacaine hydrochloride in NaCl 0.9% after microwave freeze-thaw treatment.
Reference : Ann Pharmacotherapy ; 38: 1836-1839. 2004
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionLevobupivacaine hydrochloride Local anesthetic
Compatible 1.25 mg/ml + injectionSufentanil citrate 0.001 mg/ml + Sodium chloride 0,9%
injectionSufentanil citrate Analgesic
Compatible 0.001 mg/ml + injectionLevobupivacaine hydrochloride 1.25 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% -30°C Protect from light
injection Levobupivacaine hydrochloride 1,25 mg/ml
injection Sufentanil citrate 0,001 mg/ml
120 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
injection Levobupivacaine hydrochloride 1,25 mg/ml
injection Sufentanil citrate 0,001 mg/ml
70 Day
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