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References   References 1932  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2059
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Zhang Y.
Title : Compatibility and stability of Aloxi (palonosetron hydrochloride) admixed with dexamethasone sodium phosphate.
Reference : Int J Pharm Compound ; 8,5: 398-403. 2004
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0,2 >> 0,4 mg/ml + injectionPalonosetron hydrochloride 5 & 25 µg/ml + NaCl 0,9% or Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 5 & 25 µg/ml + injectionDexamethasone sodium phosphate 0,2 >> 0,4 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Palonosetron hydrochloride 5 µg/ml
injection Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Palonosetron hydrochloride 5 µg/ml
injection Dexamethasone sodium phosphate 0,2 & 0,4 mg/ml
14 Day
Polypropylene NaCl 0,9% or Glucose 5% 25°C Light
injection Palonosetron hydrochloride 25 µg/ml
injection Dexamethasone sodium phosphate 0,33 mg/ml
48 Hour
Polypropylene NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Palonosetron hydrochloride 25 µg/ml
injection Dexamethasone sodium phosphate 0,33 mg/ml
14 Day
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