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References   References 191  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/45/10/2079
Research teams : Lawrence - The University of Kansas, Department of Pharmaceutical Chemistry
Authors : Riley CM.
Title : Stability of milrinone and digoxin, furosemide, procainamide hydrochloride, propranolol hydrochloride, quinidine gluconate, or verapamil hydrochloride in 5% dextrose injection.
Reference : Am J Hosp Pharm ; 45: 2079-2091. 1988
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionDigoxin Cardiotonic
Compatible 50 & 125 µg/ml + injectionMilrinone lactate 0.1 & 0.35 mg/ml + Glucose 5%
injectionFurosemide Diuretic
Incompatible 4 & 5 mg/ml + injectionMilrinone lactate 0.100 & 0.350 mg/ml + Glucose 5%
injectionMilrinone lactate Cardiotonic
Compatible 0.1 & 0.35 mg/ml + injectionDigoxin 50 & 125 µg/ml + Glucose 5%
Incompatible 0.100 & 0.350 mg/ml + injectionFurosemide 4 & 5 mg/ml + Glucose 5%
Incompatible 0.175 & 0.200 mg/ml + injectionProcainamide hydrochloride 1 >> 4 mg/ml + Glucose 5%
Compatible 0.100 & 0.350 mg/ml + injectionPropranolol hydrochloride 0.3 & 0.5 mg/ml + Glucose 5%
Compatible 0.175 & 0.200 mg/ml + injectionQuinidine gluconate 5 & 10 mg/ml + Glucose 5%
Compatible 0.100 & 0.350 mg/ml + injectionVerapamil hydrochloride 1 & 1.25 mg/ml + Glucose 5%
injectionProcainamide hydrochloride Anti-arrhythmic
Incompatible 1 >> 4 mg/ml + injectionMilrinone lactate 0.175 & 0.200 mg/ml + Glucose 5%
injectionPropranolol hydrochloride Beta-blocker
Compatible 0.3 & 0.5 mg/ml + injectionMilrinone lactate 0.100 & 0.350 mg/ml + Glucose 5%
injectionQuinidine gluconate Anti-arrhythmic
Compatible 5 & 10 mg/ml + injectionMilrinone lactate 0.175 & 0.200 mg/ml + Glucose 5%
injectionVerapamil hydrochloride Anti-arrhythmic
Compatible 1 & 1.25 mg/ml + injectionMilrinone lactate 0.100 & 0.350 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,1 mg/ml
injection Digoxin 125 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,35 mg/ml
injection Digoxin 50 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,35 mg/ml
injection Propranolol hydrochloride 0,3 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,1 mg/ml
injection Propranolol hydrochloride 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,175 mg/ml
injection Quinidine gluconate 5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Quinidine gluconate 10 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,35 mg/ml
injection Verapamil hydrochloride 1 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,1 mg/ml
injection Verapamil hydrochloride 1,25 mg/ml
4 Hour
  Mentions Légales