Last update :
14/12/2024
References   References 1878  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=1706

Research teams : Athens - University of Georgia, College of Pharmacy
Authors : Musami P, Stewart JT, Will Taylor E.
Title : Stability of zidovudine and dobutamine hydrochloride injections in 0.9% sodium chloride and 5% dextrose injections stored at ambient temperature (23±2°C) and 4°C in 50 ml polyvinyl chloride bags up to 24 hours.
Reference : Int J Pharm Compound ; 8, 1: 73-76. 2004

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
No visual inspection
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionDobutamine hydrochloride Cardiotonic
Compatible 1 mg/ml + injectionZidovudine 2 mg/ml + Sodium chloride 0,9%
injectionZidovudine Antiviral
Compatible 2 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C Light
injection Zidovudine 2 mg/ml
injection Dobutamine hydrochloride 1 mg/ml
24 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Not specified
injection Zidovudine 2 mg/ml
injection Dobutamine hydrochloride 1 mg/ml
24 Hour

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