Last update :
27/11/2024
References   References 1832  
Type : Journal

Research teams : Jena - Universitätkinikum Jena
Authors : Hartmann M, Knoth H, K?ler W, Meissner W.
Title : Stability of fentanyl/ropivacain preparations for epidural application.
Reference : Pharmazie ; 6 2003

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
Method not shown but the article refers to a validated method
No visual inspection

List of drugs
injectionFentanyl citrate Analgesic
Factors which affect stability Container Polyvinyl chloride Induces Adsorption
Compatible 3 µg/ml + injectionRopivacain hydrochloride 1,5 mg/ml + Sodium chloride 0,9%
injectionRopivacain hydrochloride Local anesthetic
Compatible 1,5 mg/ml + injectionFentanyl citrate 3 µg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 2-8°C Protect from light
injection Ropivacain hydrochloride 1,5 mg/ml
injection Fentanyl citrate 3 µg/ml
51 Day
Glass Sodium chloride 0,9% 20°C With or without light
injection Ropivacain hydrochloride 1,5 mg/ml
injection Fentanyl citrate 3 µg/ml
51 Day
Polyvinyl chloride Sodium chloride 0,9% 2-8°C Protect from light
injection Ropivacain hydrochloride 1,5 mg/ml
injection Fentanyl citrate 3 µg/ml
11 Day
Polyvinyl chloride Sodium chloride 0,9% 20°C With or without light
injection Ropivacain hydrochloride 1,5 mg/ml
injection Fentanyl citrate 3 µg/ml
11 Day
Ethylene vinyl acetate Sodium chloride 0,9% 2-8°C Protect from light
injection Ropivacain hydrochloride 1,5 mg/ml
injection Fentanyl citrate 3 µg/ml
51 Day
Ethylene vinyl acetate Sodium chloride 0,9% 20°C With or without light
injection Ropivacain hydrochloride 1,5 mg/ml
injection Fentanyl citrate 3 µg/ml
51 Day

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