Last update :
08/11/2024
References   References 1824  
Type : Journal

Research teams : Skokie - Pfizer Inc
Authors : Crane IM, Mulhern MG, Nema S.
Title : Stability of reconstituted parecoxib for injection with commonly used diluents.
Reference : J Clin Pharm Ther ; 28: 363-369. 2003

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products identified

List of drugs
injectionParecoxib sodium Analgesic
Stability in solutions Glass Sodium chloride 0,9% 16 & 20 mg/ml 25°C Light
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 16 & 20 mg/ml 5°C Protect from light
48 Hour
Stability in solutions Glass Glucose 5% 16 & 20 mg/ml 25°C Light
48 Hour
Stability in solutions Glass Glucose 5% 16 & 20 mg/ml 5°C Protect from light
48 Hour
Stability in solutions Glass NaCl 0,9% + antibacterial 16 & 20 mg/ml 25°C Light
48 Hour
Stability in solutions Glass NaCl 0,9% + antibacterial 16 & 20 mg/ml 5°C Protect from light
48 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 13,3 & 20 mg/ml 25°C Light
48 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 13,3 & 20 mg/ml 5°C Protect from light
48 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 13,3 & 20 mg/ml 25°C Light
48 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 13,3 & 20 mg/ml 5°C Protect from light
48 Hour
Stability in solutions Polypropylen Syringe NaCl 0,9% + antibacterial 13,3 & 20 mg/ml 25°C Light
48 Hour
Stability in solutions Polypropylen Syringe NaCl 0,9% + antibacterial 13,3 & 20 mg/ml 5°C Protect from light
48 Hour

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