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References   References 175  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/51/3/368
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Pearson SD.
Title : Storage of lorazepam in three injectable solutions in polyvinyl chloride and polyolefin bags.
Reference : Am J Hosp Pharm ; 51: 368-372. 1994
Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No visual inspection
List of drugs
injectionLorazepam Anxiolytic
Factors which affect stability Container Polyvinyl chloride Induces Adsorption
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 mg/ml -20°C Protect from light
7 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 mg/ml 24°C Protect from light
7 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 mg/ml 37°C Protect from light
3 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyolefine Ringer’s lactate solution 0,1 mg/ml -20°C Protect from light
7 Day
Stability in solutions Polyolefine Ringer’s lactate solution 0,1 mg/ml 24°C Protect from light
7 Day
Stability in solutions Polyolefine Ringer’s lactate solution 0,1 mg/ml 37°C Protect from light
3 Day
Stability in solutions Polyolefine Ringer’s lactate solution 0,1 mg/ml 4°C Protect from light
7 Day
  Mentions Légales