Last update :
08/11/2024
References   References 1734  
Type : Journal
Web link : https://doi.org/10.1016/0731-7085(93)80181-Y

Research teams : Manchester - Christie Hospital NHS Trust
Authors : Hadfield JA, McGown AT, Dawson MJ, Thatcher N, Fox BW.
Title : The suitability of carboplatin solutions for 14-day continuous infusion by ambulatory pump : an HPLC-dynamic FAB study.
Reference : J Pharm Biomed Anal ; 11: 723-727. 1993

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
Comments : 
Unencrypted results (eg graphic)
Degradation products detected but not quantified

List of drugs
injectionCarboplatin Anticancer drug
Stability in solutions Polyvinyl chloride Glucose 5% 6 mg/ml 37°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride None 10 mg/ml 37°C Protect from light
14 Day

  Mentions Légales