Last update :
19/11/2024
References   References 1674  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF.
Title : Concentration dependency of vancomycin hydrochloride compatibility with beta-lactam antibiotics during simulated Y-site administration.
Reference : Hosp Pharm ; 33: 1515-1522. 1998

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmpicillin sodium Antibiotic
Incompatible 250 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 250 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 >> 50 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 1/0.5 >> 50/25 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 250-125 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1/0.5 >> 250/125 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionCefazolin sodium Antibiotic
Incompatible 50 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 10 >> 200 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 ; 10 & 200 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionCefonicid sodium Antibiotic
Compatible 1 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 225 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Incompatible 10 >> 225 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
injectionCefotaxime sodium Antibiotic
Incompatible 50 & 200 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 & 10 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 200 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionCefoxitin sodium Antibiotic
Incompatible 10 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 180 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 50 & 180 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
injectionCeftazidime Antibiotic
Compatible 1 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 10 >> 200 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 200 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionCeftizoxime sodium Antibiotic
Compatible 1 >> 280 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Incompatible 280 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 50 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
injectionCeftriaxone disodium Antibiotic
Incompatible 1 >> 250 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 250 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionCefuroxime sodium Antibiotic
Incompatible 10 >> 150 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 150 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionNafcillin sodium Antibiotic
Compatible 1 mg/ml + injectionVancomycin hydrochloride 2 & 20 mg/ml + Glucose 5%
Incompatible 10 >> 250 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Incompatible 10 >> 250 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionPiperacillin sodium Antibiotic
Incompatible 10 >> 250 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1 >> 200 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionPiperacillin sodium / tazobactam Antibiotic
Incompatible 10/1.25 >> 200/25 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1/0.125 >> 200/25 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
Compatible 1/0.125 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
injectionTicarcillin / clavulanic acid Antibiotic
Incompatible 1/0.034 >> 200/6.7 mg/ml + injectionVancomycin hydrochloride 20 mg/ml + Glucose 5%
Compatible 1/0.034 >> 200/6.7 mg/ml + injectionVancomycin hydrochloride 2 mg/ml + Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Incompatible 20 mg/ml + injectionAmpicillin sodium 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionAmpicillin sodium 1 >> 50 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionAmpicillin sodium 1 >> 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionAmpicillin sodium - sulbactam sodium 1/0.5 >> 50/25 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionAmpicillin sodium - sulbactam sodium 250-125 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionAmpicillin sodium - sulbactam sodium 1/0.5 >> 250/125 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCefazolin sodium 10 >> 200 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCefazolin sodium 1 ; 10 & 200 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionCefazolin sodium 50 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCefazolin sodium 1 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCefonicid sodium 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCefonicid sodium 1 >> 225 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCefonicid sodium 10 >> 225 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCefotaxime sodium 1 & 10 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCefotaxime sodium 1 >> 200 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCefotaxime sodium 50 & 200 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCefoxitin sodium 1 >> 180 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCefoxitin sodium 50 & 180 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCefoxitin sodium 1 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCefoxitin sodium 10 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCeftazidime 1 >> 200 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCeftazidime 1 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCeftazidime 10 >> 200 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCeftizoxime sodium 1 >> 50 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCeftizoxime sodium 1 >> 280 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCeftizoxime sodium 280 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCeftriaxone disodium 1 >> 250 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCeftriaxone disodium 1 >> 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionCefuroxime sodium 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCefuroxime sodium 1 >> 150 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionCefuroxime sodium 10 >> 150 mg/ml + Glucose 5%
Compatible 2 & 20 mg/ml + injectionNafcillin sodium 1 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionNafcillin sodium 10 >> 250 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionNafcillin sodium 10 >> 250 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionPiperacillin sodium 10 >> 250 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionPiperacillin sodium 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPiperacillin sodium 1 >> 200 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionPiperacillin sodium / tazobactam 10/1.25 >> 200/25 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 1/0.125 >> 200/25 mg/ml + Glucose 5%
Compatible 20 mg/ml + injectionPiperacillin sodium / tazobactam 1/0.125 mg/ml + Glucose 5%
Incompatible 20 mg/ml + injectionTicarcillin / clavulanic acid 1/0.034 >> 200/6.7 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionTicarcillin / clavulanic acid 1/0.034 >> 200/6.7 mg/ml + Glucose 5%

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