Last update :
08/11/2024
References   References 1660  
Type : Journal
Web link : http://springerlink.metapress.com/content/gt5q55l783518543/?p=dbaa31176998409794fbdf4230c6cea3&pi=6

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Thiesen J, Krämer I.
Title : Physico-chemical stability of docetaxel premix solution and docetaxel infusion solutions in PVC bags and polyolefine containers.
Reference : Pharm World Sci ; 21: 137-141. 1999

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionDocetaxel Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,3 & 0,9 mg/ml 25°C Protect from light
28 Day
Stability in solutions Glass specific solvent 10 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass specific solvent 10 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0,3 & 0,9 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polypropylene Glucose 5% 0,3 & 0,9 mg/ml 25°C Protect from light
28 Day

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