Last update :
08/11/2024
References   References 1617  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/59/6/539

Research teams : Los Angeles - University of Southern california, School of Pharmacy
Authors : Li WY, Koda RT.
Title : Stability of irinotecan hydrochloride in aqueous solutions.
Reference : Am J Health-Syst Pharm ; 59: 539-544. 2002

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - fluorescence detector
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products identified and quantified
No visual inspection

List of drugs
injectionIrinotecan Anticancer drug
Factors which affect stability pH pH < 6 Induces Enhanced stability
Stability in solutions Glass Sodium chloride 0,9% 0,02 mg/ml 25°C Not specified
1 Hour
Stability in solutions Glass Glucose 5% 0,02 mg/ml 25°C Not specified
24 Hour

  Mentions Légales