Last update :
27/11/2024
References   References 151  
Type : Journal

Research teams : Los Angeles - University of Southern california, School of Pharmacy
Authors : Burm JP, Choi JS, Jhee SS, Chin A, Ulrich RW, Gill MA.
Title : Stability of paclitaxel and fluconazole during simulated Y-site administration.
Reference : Am J Hosp Pharm ; 51: 2704-2706. 1994

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionPaclitaxel 0,3 & 1,2 mg/ml + Glucose 5%
injectionPaclitaxel Anticancer drug
Compatible 0,3 & 1,2 mg/ml + injectionFluconazole 2 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 23°C Light
injection Paclitaxel 0,3 & 1,2 mg/ml
injection Fluconazole 2 mg/ml
4 Hour

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