Last update :
19/11/2024
References   References 1477  
Type : Journal
Web link : https://doi.org/10.1016/0731-7085(96)01847-X

Research teams : Murray Hill - Ohmeda Pharmaceutical Products Division
Authors : Murthy SS, Brittain HG.
Title : Stability of revex, nalmefene hydrochloride injection, in injectable solutions.
Reference : J Pharm Biomed Anal ; 15: 221-226. 1996

Level of Evidence : 
Level of evidence C+
Physical stability : 
Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionNalmefene Various
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 µg/ml 21°C Not specified
72 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 µg/ml 40°C Not specified
72 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 µg/ml 4°C Protect from light
72 Hour
Stability in solutions Glass Ringer’s lactate solution 10 µg/ml 21°C Not specified
72 Hour
Stability in solutions Glass Ringer’s lactate solution 10 µg/ml 40°C Not specified
72 Hour
Stability in solutions Glass Ringer’s lactate solution 10 µg/ml 4°C Protect from light
72 Hour
Stability in solutions Glass Sodium chloride 0,45% 10 µg/ml 21°C Not specified
72 Hour
Stability in solutions Glass Sodium chloride 0,45% 10 µg/ml 40°C Not specified
72 Hour
Stability in solutions Glass Sodium chloride 0,45% 10 µg/ml 4°C Protect from light
72 Hour

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