Last update :
08/11/2024
InfoStab
Infostab
List of drugs
List of drugs
Summary lists
Summary lists
Search for compatibilities
Search for compatibilities
Y-site compatibility table
Y-site compatibility table
References
References
Research teams
Research teams
valistab
valistab
Poster
Poster
Links
Links
Sponsors
Sponsors
Authors
Authors
User’s guide
User’s guide
Newsletter
Newsletter
References   References 1425  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/5/2/75
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Krämer I, Thiesen J.
Title : Stability of topotecan infusion solutions in polyvinylchloride bags and elastomeric portable infusion devices.
Reference : J Oncol Pharm Practice ; 5: 75-82. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
List of drugs
injectionTopotecan Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Water for Injection 1 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 25°C Protect from light
28 Day
  Mentions Légales