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References   References 1292  
Type : Journal
Research teams : Cardiff - University of Wales, Department of Pharmacy
Authors : Grassby PF, Roberts DE.
Title : Stability of epidural opiate solutions in 0.9 per cent sodium chloride infusion bags.
Reference : Int J Pharm Pract ; 3: 174-177. 1995
Level of Evidence : 
Level of evidence B
Physical stability : 
Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products detected but not quantified
List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionDiamorphine hydrochloride Analgesic
injectionPethidine hydrochloride Analgesic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2,5 mg/ml 25°C Light
24 Day
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 25°C Light
injection Diamorphine hydrochloride 0,125 mg/ml
injection Bupivacaine hydrochloride 1,25 mg/ml
28 Day
  Mentions Légales