Last update :
08/11/2024
References   References 1237  
Type : Journal

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Keusters L, Stolk LML, Umans R, Van Asten P.
Title : Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at -20°C and thawing by microwave radiation.
Reference : Pharm Weekbl [Sci] ; 8: 194-197. 1986

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Thin Layer Chromatography
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml -20°C Protect from light
14 Day
injectionEpirubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml -20°C Protect from light
28 Day

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