Bibliographie - 1075 - Stabilis 4.0

Last update :
19/11/2024

References

References 1075

Type :

Journal

Web link :

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGX-3ST2874-3&_user=1592607&_coverDate=10%2F31%2F1997&_rdoc=3&_fmt=summary&_orig=browse&_srch=doc-info(%23toc%235266%231997%23999839997%2311428%23FLT%23display%23Volume)&_cdi=5266&_sort=d&_docanch

Research teams :

King of Prussia - SmithKline Beecham Pharmaceuticals

Authors :

Craig SB, Bhatt UH, Patel K.

Title :

Stability and compatibility of topotecan hydrochloride for injection with common infusion solutions and containers.

Reference :

J Pharm Biomed Anal ; 16: 199-205. 1997

Level of Evidence :

Level of evidence B

AideBibliographie

Physical stability :

Chemical stability :

Stability defined as 95% of the initial concentration

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Other methods :

Comments :

No visual inspection

Degradation products not observed in real conditions

List of drugs

injection

Topotecan

Anticancer drug

Stability in solutions

Glass

NaCl 0,9% or Glucose 5%

0,05 mg/ml

23-24°C

Light

24

Hour

Stability in solutions

Glass

NaCl 0,9% or Glucose 5%

0,05 mg/ml

5°C

Protect from light

7

Day

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

0,025 mg/ml

23°C-24°C

Light

24

Hour

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

0,025 mg/ml

5°C

Protect from light

7

Day

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

0,05 mg/ml

23-24°C

Light

24

Hour

Stability in solutions

Polyvinyl chloride

NaCl 0,9% or Glucose 5%

0,05 mg/ml

5°C

Protect from light

7

Day

Stability in solutions

Polyolefine

NaCl 0,9% or Glucose 5%

0,05 mg/ml

23-24°C

Light

24

Hour

Stability in solutions

Polyolefine

NaCl 0,9% or Glucose 5%

0,05 mg/ml

5°C

Protect from light

7

Day

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