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References   References 1027  
Type : Journal
Research teams : Mac Gaw Park - American Critical Care
Authors : Wagenknecht DM, Baaske DM, Alam AS, Carter JE, Shah J.
Title : Stability of nitroglycerin solutions in polyolefin and glass containers.
Reference : Am J Hosp Pharm ; 41: 1807-1811. 1984
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
List of drugs
injectionNitroglycerin Vasodilator
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,2 & 0,4 mg/ml 18-27°C Light
28 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,2 & 0,4 mg/ml 5°C Protect from light
28 Day
Stability in solutions Glass Ringer’s lactate solution 0,2 & 0,4 mg/ml 18-27°C Light
28 Day
Stability in solutions Glass Ringer’s lactate solution 0,2 & 0,4 mg/ml 5°C Protect from light
28 Day
Stability in solutions Glass Sodium chloride 0,45% 0,2 & 0,4 mg/ml 18-27°C Light
28 Day
Stability in solutions Glass Sodium chloride 0,45% 0,2 & 0,4 mg/ml 5°C Protect from light
28 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,2 & 0,4 mg/ml 18-27°C Light
28 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,2 & 0,4 mg/ml 5°C Protect from light
28 Day
Stability in solutions Polyolefine Ringer’s lactate solution 0,2 & 0,4 mg/ml 18-27°C Light
28 Day
Stability in solutions Polyolefine Ringer’s lactate solution 0,2 & 0,4 mg/ml 5°C Protect from light
28 Day
Stability in solutions Polyolefine Sodium chloride 0,45% 0,2 & 0,4 mg/ml 18-27°C Light
28 Day
Stability in solutions Polyolefine Sodium chloride 0,45% 0,2 & 0,4 mg/ml 5°C Protect from light
28 Day
  Mentions Légales