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References   References 1026  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/56/9/875
Research teams : Philadelphia - Philadelphia College of Pharmacy and Science
Authors : Mayron D, Gennaro AR.
Title : Stability and compatibility of topotecan hydrochloride with selected drugs.
Reference : Am J Health-Syst Pharm ; 56: 875-881. 1999
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
List of drugs
injectionCarboplatin Anticancer drug
Compatible 0.9 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 5.76 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionCisplatin Anticancer drug
Compatible 0.168 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionCyclophosphamide Anticancer drug
Compatible 20 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + injectionTopotecan 0.056 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + injectionTopotecan 0.056 mg/ml + Glucose 5%
injectionDoxorubicin hydrochloride Anticancer drug
Compatible 2 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionFluorouracil Anticancer drug
Incompatible 50 mg/ml + injectionTopotecan 0.056 mg/ml + Sodium chloride 0,9%
Compatible 50 mg/ml + injectionTopotecan 0.056 mg/ml + Glucose 5%
injectionGranisetron hydrochloride Antiemetic
Compatible 0.02 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionIfosfamide Anticancer drug
Compatible 14.28 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 2.4 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 1.72 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionMitomycin Anticancer drug
Incompatible 0.084 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 0.48 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionPaclitaxel Anticancer drug
Compatible 0.54 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionProchlorperazine edysilate Neuroleptic
Compatible 0.192 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 47.6/1.6 mg/ml + injectionTopotecan 0.056 mg/ml + Sodium chloride 0,9%
Incompatible 47.6/1.6 mg/ml + injectionTopotecan 0.056 mg/ml + Glucose 5%
injectionTopotecan Anticancer drug
Compatible 0.056 mg/ml + injectionCarboplatin 0.9 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionCimetidine hydrochloride 5.76 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionCisplatin 0.168 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionCyclophosphamide 20 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.056 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Sodium chloride 0,9%
Compatible 0.056 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Glucose 5%
Compatible 0.056 mg/ml + injectionDoxorubicin hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionEtoposide 0.4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.056 mg/ml + injectionFluorouracil 50 mg/ml + Sodium chloride 0,9%
Compatible 0.056 mg/ml + injectionFluorouracil 50 mg/ml + Glucose 5%
Compatible 0.056 mg/ml + injectionGranisetron hydrochloride 0.02 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionIfosfamide 14.28 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionMethylprednisolone sodium succinate 2.4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionMetoclopramide hydrochloride 1.72 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.056 mg/ml + injectionMitomycin 0.084 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionOndansetron hydrochloride 0.48 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionPaclitaxel 0.54 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionProchlorperazine edysilate 0.192 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 mg/ml + injectionTicarcillin / clavulanic acid 47.6/1.6 mg/ml + Sodium chloride 0,9%
Incompatible 0.056 mg/ml + injectionTicarcillin / clavulanic acid 47.6/1.6 mg/ml + Glucose 5%
Compatible 0.056 mg/ml + injectionVincristine sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionVincristine sulfate Anticancer drug
Compatible 1 mg/ml + injectionTopotecan 0.056 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Carboplatin 0,45 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Cimetidine hydrochloride 2,88 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Cisplatin 0,084 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Cyclophosphamide 10 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Doxorubicin hydrochloride 1 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Etoposide 0,2 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Granisetron hydrochloride 0,01 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Ifosfamide 7,14 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Methylprednisolone sodium succinate 1,2 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Metoclopramide hydrochloride 0,86 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Ondansetron hydrochloride 0,24 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Paclitaxel 0,27 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Prochlorperazine edysilate 0,096 mg/ml
4 Hour
Not specified NaCl 0,9% or Glucose 5% 20°C-23°C Light
injection Topotecan 0,028 mg/ml
injection Vincristine sulfate 0,5 mg/ml
4 Hour
  Mentions Légales